Yes and no. If you starting messing with too many variables, you can definitely get it to run like crap.
If you take things one at a time, then no, you should be able to tune it to run great in all RPMs. Like mine!
Here's what I did in order:
TOR shorties from the get go
-Didn't touch the pilots
Freak/carb screws/160s
-Balance carbs
-Didn't touch the pilots
Epcos
-Balance carbs
-Didn't touch the pilots
Drill slides & TBS needles
-Balance carbs
-Didn't touch the pilots
Thumb screws
-Balance carbs
-Didn't touch the pilots
150s (160s too rich)
-Balance carbs
-Didn't touch the pilots
Note the theme....
