Started with Willie&Max SB707 Deluxe Compact Slant 12" wide x 9.5" high x 5.5" deep. Way too small and hold a lot of water if riding in the wet.
Then went thru 2 sets of Saddlemen 5392 Jumbo Slant Drifters: 17.5" x 10.5" x 6" (2200 cu. in. capacity per set) After a short while the size still felt too small. They seemed to be very resistant to water intake (not waterproof, but good enough with the box top). The slant looks good but takes up useable space. The plastic backs on 2 sets cracked badly within a year of use. I think the instructions call for no more than 10lbs per bag. No raincovers. 3 each quarter turn locks to remove but are better firm (rail) mounted.
Now running TourMaster Cruiser II XL (standards, not slants): 10"h x 18"w x 6"d, 2160 cubic in. They don't seem as wide as the Drifters and are not as easy to get in and out of, but have a much heftier feel. The first time I rode with them in a torrential rain the included raincovers were holding about a gallon each when I parked. No more rain covers. After riding in rain for a 3500 mile week everything inside was wet, but the bags held up very well. Zippers to remove. I went with rails that support the bags from the bottom so hopefully they'll last longer.
No clearance issues on any of the bags. I think if you were going to get Drifters, I go with super jumbos, but then I carry a lot of crap.