We have a 2001 Jeep Grand Cherokee 256,000 miles 4wd 4.0L straight-6 and the only recurring irritating problem is the 42RE transmission. Specifically the governor pressure solenoid and pressure sensor which fail about every 3 years, annoying but not the worst. I wonder how many shops sell entire transmissions to people when this part fails though. The 42re trans was a distant descendant of the good old 904 Chrysler transmission with an overdrive and electronics added which was a real bandaid approach.