I had a much milder form of a similar problem while riding. I got a new seat that removes most of the weight from that spot. Also, putting running boards on the bike allows for changes in seating position so I can easily change the spot where the weight is concentrated if it starts to hurt. Despite a substantial belly I have almost no butt so all my (over)weight was on that tender area. About 18 months ago I took the bike from Iowa to California and back. It was still uncomfortable by the end of the day, but much better than just a few hours on the stock seat.
I tried the Airhawk seat cover and that helped quite a bit, but with the other changes I seldom need it anymore.