Paul,
Moe's route is the quickest by far. "long day" is very optimistic by my arse standards though. I respectfully consider Moe a seasoned long distance rider and If he says its doable I have no reason to doubt. I, on the other hand, can get pretty burned out by a hard 250 mile day. I make a few trips to Kingsport/Johnson City every year by cage and have yet to make that distance in under 6-1/2 hours. For me, scooter time adds considerable time. I'm thinkin you could do it in a looong day, but, I know I sure enjoy a nights rest half way. I Only say this because I think there are far more like me than there are like Moe.