Well I'm in favor of going from Venice - but would mean sailing already on Wednesday mid-afternoon getting there Thursday afternoon:
Departure Arrival Vessel Company
1. VENICE-IGOUMENITSA 27-07-2011, 14:00 28-07-2011 , 11:55 EUROPA PALACE MINOAN LINES
2. IGOUMENITSA-VENICE 02-08-2011, 09:00 03-08-2011 , 08:00 EUROPA PALACE MINOAN LINES
Or on Thursday mid-afternoon from Ancona - getting there Friday morning:
Departure Arrival Vessel Company
1. ANCONA-IGOUMENITSA 28-07-2011, 15:30 29-07-2011 , 08:00 CRUISE OLYMPIA MINOAN LINES
2. IGOUMENITSA-ANCONA 02-08-2011, 23:59 03-08-2011 , 14:30 CRUISE OLYMPIA MINOAN LINES
What I do know from lots of experience (once every year), is that we - the family & I - have always gone from Ancona with the car and know that if you book outbound & return with the same company you get a small reduction.
It always meant SETTING OFF from Zurzach, Switzerland at 05:00 AM ! !
Includes two stops: One at Swiss Italy boarder (refuel as it's cheaper), one south of Bologna and then Ancona.
All motor ways....
Just my 2p