I love driving in NYC, it's probably one of the easiest major cities to navigate thru. I sure wouldn't want to do it every day, but occasionally it's a hoot!
But, taking the train in is good advice if you don't relish driving. You can park at two places now on the NJ side and take the 5-10 minute ride into the city. I like the Statue of Liberty State Park station, you can park over night there for $5 I believe, and it is a safe and patrolled parking lot. You take the NJT train (ticket is included wit the parking fee) and than the PATH train into Penn Station.
Or park at the new facility in Secaucus (Exit 15x on the NJTP) and take the 2 minute NJ Transit train into Penn Station. I think the round-trip ticket is less than $5. I'm not certain on parking, but think it is probably not an overnight facility. I've used that train station plenty, but we stay at a nearby Marriott and use their shuttle for transportation.
Where in Germany is your wife from?
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Driving to manhatten next week taking my wife to the german consulate .I think i would rather take a bullet. 
So, why not take the train in?
If there's no train stop near your home, you could drive to one and still save the hassle & expense of driving into the city.
Once you're in, take the subway where you need to go. Easy. 
