One of the 7 natural wonders: The Grand Canyon. Figuring I may never get back, we sprung for a flight over it, then helicoptered down in, then a boat ride on the river, then lunch with the Native Americans who own the land there. I think it was around $350 per person? I don't recall the price. Well worth it.

Hoover Dam is awesome

Blue Man Group

Cirque De Soleil

Fremont street with the light show on the roof. Walk in the footsteps of the old school gangsters at the un-refurbished section of the strip.
http://www.youtube.com/watch?v=6jbj7z-yTNY
The show is done with sequenced light bulbs, not projection, and there's no charge to see it.

They say Red Rocks is incredible too, but we didn't get there

If comfort and a memorable place to stay are on the list, The Bellagio won't disappoint.

As you likely are aware, at Vegas you are within driving distance to the west coast, in case any of the party want to dip a toe into the Pacific Ocean. I believe the distance is around 200 miles? I'm not sure.