I'm a long time Garmin guy. I currently run a 2720 on my bikes. I have them both hardwired and use a RAM handlebar mount on both so I can move the GPS back and forth. I have the audio promps (UK voice, of course) routed through a simple passive mixer with my Sirus radio into my headset.
I like the 27xx series because of the great screen resolution and 3D view. The newer 2730 has XM built in which would reduce the number of devices on the bike.