With so many factors to consider who could pick just one? I guess it would depend on the mood I'm in.
For a good sit down type of hamburger place, Fudruckers would definitely get my vote
For somewhere in between sit down and fast food, 5 Guys. If you've never been to one I'd highly suggest looking into it, very simple menu, ample portions, cooked to order, excellent fires, pretty much, they do the basics perfectly.
As far as fast food is concerned I would have to break it up into risk factor...
For a low risk (with the exception of fat, calories, ect...) fast food burger I really like Burger King, their new angry whopper is really good, all their regular burgers a pretty tasty too.
If I'm in in the mood to throw caution to the wind and put my own personal safety to chance, Jack in the box makes some great burgers, the sour dough jack is great, but then again so is the risk of food poisoning.
Also if I'm in the mood for personal risk, and I now I'll get some disagreement on this choice, but white castle burgers are also really tasty. They're greasy as can be but tasty none the less.
My least favorite, McDonalds, you'd have to drag me to that place and even then you'd have to force a hamburger from there down my throat.