I usually hit reserve at 120-125 miles, but my odometer reads 2-3% less miles than actually traveled. My best was 165 to reserve (all highway 65-70 mph). I allow a max. of 20 miles on reserve. I almost always run until I hit reserve, notice the odometer mileage, and make sure I get gas before 20 miles.
Not mentioned here, but everyone doesn't fill their tank to the same level. I fill mine to the top of the inner ring while holding the bike up straight.