Not really. You don't need to drop the rear tire off, but you need to have the bike suspended, such that the rear tire is off the ground. Then you can unbolt the rear fender, lower it from the fender rails and kind of slide it back over the tire. Then the airbox comes out under the frame cross rail and over the rear tire. Of course, if you don't mind destroying the airbox, you can probably dremel the thing into manageable chunks and remove it piecemeal from the bike.
