Grandmother's Plymouth 4 powered Henderson really sounded nice. Too bad she sold it to move to the west coast between VE and VJ day.
I do like the sound of a real (= not jap) V2 with cams and pipes, especially my old flathead 80, Panhead and Ironhead. Both the old 650 Triumph and my America have a special sound to them. The Brit build Indian 650 a friend of mine had until the gearbox locked up at 60 MPH had a really good sound to it. Seems he was putting a bit too much effort into shifting fast and bent a shift fork.
On 4 wheels, the early MoPar Hemis had a really good sound, but the best 2 were The 59A and 59L block Ford products and (gasp) pre 1950 Studebaker 6's with split manifolds.