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How does something like that effect handling?
Maybe one or more will chime in.
Identical diameter wheels will track in the same arc of rotation , when you mix them , the smaller diameter wheel will follow a tighter arc than the larger wheel . In a curve they tend to follow different arcs and "fight" against each other , resulting in a less than harmonious turn . Notice sport bike wheels as opposed to a bar hopper .
The Vorlons have a saying , "We are masters of rotational applied physics" . 
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