Impossible to pick a best single guitarist as there are so many contributors to the evolution of the instrument: Les Paul for developing multi-tracking, T-Bone Walker for soloing, Jimi Hendrix for turning the world upside down, George Harrison for recoding feedback (I Feel Fine), Link Wray for distortion, Townshend, Beck and Page for riffing, Duane Allman for melody, Tommy Iommi for volume...this list could go on for days...