To patch from the inside or add a tube, you have to pull the wheel, remove the tire, costs more. I don't think it's worth it. If the hole is so big the plug won't work, you should just replace the tire. I've plugged from roofing nails, 10d nails, drywall screws, with no problems. The resulting repairs lasted thousands of miles, until the tread wore out. I did Fort Lauderdale to Daytona and back on a plugged tire, two-up, 100plus, no worries.
