If you're not used to long runs, take a minimum of 20 minutes at every gas stop and stop for a leisurely lunch at about the 250-275 mile point. Once the ache begins, it's too late! It's all about the journey anyway. On the way back, you can push the envelope a bit to see what works for you.
I refuel at least once on every ride (except when I take the scooter). Gotta confess, I'm diggin' that little thing.
