A question like that draws every iron butt on the forum out of the woodwork. So, here's a different prespective. I'm 58 and really enjoy traveling on my America, but I don't consider me or the bike really designed for too long a distances. My longest is 450 miles and it was OK, but I was pretty worn out at the end. I've made a number of 250 mile trips that were very enjoyable and not taxing at all. If I had to do more than that I would make sure I was well rested and prepared for an "adventure".
You shouldn't have a problem, especially if you focus on the fun and adventurous aspect of motorcycle traveling.