I've done a couple of 8 hour drive days in relative comfort. I have the stock TA seat, but on long trips I use my Kuryakyn Tombstone Backrest bag between me and the sissy bar. Being able to relax my back makes a major difference. I also wear a face shield and earplugs on long trips. I have a Clearview 17" Summer Screen replacement which gets the wind off my body and head.
I have the Triumph slant bags that primarily carry the stuff other than packed clothes, etc. I can fit a T-Bag behind the sissy bar on the rack. The T-Bag and Backrest bag carry all the stuff I need to take inside.
I know there are bikes that might be better designed for touring, but that's just one part of my riding. I love all the local cruising, Sunday afternoon rides, and attention stealing (from my HD friends). The TA is the best all around bike I've ever owned - not to mention I love the way it looks!