The throw-overs will scuff your fender if they are anything like my Triumph slanted bags. If you decide to use only a solo seat and bare fender, there isn't really anything to secure the bags to the fender. If you have a pillion or the Speedmaster gunslinger seat, then the rear part of the seat snugs down over the fender strap and holds it secure.
The Easybrackets hold the bags out from the bike a good inch on each side and give the bike a wider profile. It doesn't sound like much, but it's noticable if you change from one setup to the other. The throw-overs fit closer in to the bike.