Me, I think I'd take the PA Turnpike (I-76) to I-70, then I-270N around Columbus to SR-31 to Kenton. I always preferred 76 to 80 when I drove truck.
If time wasn't a factor, I'd take US-30 (Lincoln Hwy) all the way. But then, I always try to take Blue Highways whenever I can, no matter what I'm driving.
